hrp0089p2-p123 | Fat, Metabolism and Obesity P2 | ESPE2018

Allopurinol Ameliorates Non-Alcoholic Fatty Liver Disease in Rats

Anil Korkmaz Huseyin , Aktug Huseyin , Atila Dincer , Barisik Vatan , Arslan Nur , Erbas Oytun

Background: Hyperuricemia has been found to be associated with non-alcoholic fatty liver disease (NAFLD).Aim: The aim of this study was to evaluate whether allopurinol affects the course of experimental NAFLD in rats.Study Design: Mature, albino Sprague Dawley rats were fed water containing 30% fructose without ethanol for up to 8 weeks. After demonstration of steatosis in the 8th week, either allopurinol or saline was administered...

hrp0089p2-p395 | Thyroid P2 | ESPE2018

Serum Level of Biotin Rather than the Daily Dose is the Main Determinant of the Interference on Thyroid Function Assays in Patients with Biotinidase Deficiency

Paketci Ahu , Kose Engin , Calan Ozlem Gursoy , Acar Sezer , Teke Pelin , Demirci Ferhat , Abacı Ayhan , Demir Korcan , Arslan Nur , Bober Ece

Introduction: High doses of biotin are reported to cause incorrect results in various immunoassays in some patients. However, there is no systematic study regarding biotin interference in childhood.Aim: To assess thyroid function with different methods in subjects with biotinidase deficiency, to determine the factors causing interference, and to investigate the efficiency of the methods for overcoming interference.Method: The study...